The end stage of PKD in cats is a challenging time for every cat owner.
Watching your beloved cat suffer can be very emotionally stressful.
In the final stages of PKD, the kidneys are severely impaired, leading to serious health problems.
In this guide, you'll learn all about the symptoms, diagnosis, and treatment options for end-stage PKD, as well as how to improve your cat's quality of life.
Understanding the Stages of Kidney Failure in Cats

Kidney failure in cats develops gradually and is divided into four main stages. Each stage shows different symptoms and effects on the cat's health. A better understanding of these stages will help you to recognize your cat's illness early and act accordingly.
In the first stage, there are no visible symptoms and the cat's life expectancy is not affected. In the later stages, the symptoms worsen and the cat's quality of life can decrease significantly. Knowing about these stages makes it possible to start treatment early and thus slow the progression of the disease.
Life expectancy in end-stage renal failure
In the end-stage renal failure, symptoms in cats are severe, and life expectancy without treatment is only about 35 days. However, early diagnosis and consistent treatment can help extend life expectancy.
Improving the quality of life of cats in terminal disease

The quality of life of cats in end-stage renal failure can be improved by various measures. These include an adapted diet, regular medical monitoring and minimizing stress. These measures help to maintain the cat's well-being and keep its quality of life as high as possible.
Nutritional Tips for Cats in the End Stage
For cats in the end stages of renal failure, a special diet with high-quality proteins and a reduction in phosphate is important. Wet food may be preferred as it increases fluid intake and relieves the kidneys. Additives such as tuna juice can help to increase the cat's appetite.
Pathogenesis of PKD in cats
The pathogenesis of polycystic kidney disease (PKD) in cats is genetic. This disease leads to the formation of numerous fluid-filled cysts in the kidneys, which grow over time and impair normal kidney function. The disease is caused by a mutation in the PKD1 gene, which occurs primarily in certain cat breeds such as Persians and Exotic Shorthairs.
The genetic predisposition for PKD is inherited in an autosomal dominant manner, meaning that even one affected parent can pass the disease on to their offspring. Early detection of the disease is crucial as it helps to develop appropriate management strategies and improve the quality of life of affected cats.
Recognizing Symptoms of PKD in Cats
Symptoms of PKD in cats can vary, but are often similar to those of other kidney diseases. The most common signs include decreased appetite, weight loss, excessive thirst, frequent urination, and lethargy. If cat owners recognize these symptoms early , timely diagnosis and treatment can be initiated.
Diagnosis of PKD in Cats

Diagnosis of PKD in cats is mainly done through ultrasound examinations, which allow to detect cysts in the kidneys. Additionally, genetic tests can be performed to check for the presence of the PKD1 gene. These methods are crucial to detect the disease early and plan appropriate treatment strategies.
Treatment Options for PKD in Cats

Treatment for PKD in cats focuses on relieving symptoms and supporting kidney function for as long as possible. This includes dietary adjustments, medications to control blood pressure, and fluid therapy. Regular veterinary check-ups are crucial to monitor disease progression and maintain the cat's quality of life .
Breeding management to prevent PKD
To prevent the spread of PKD in cat breeding, breeders rely on genetic testing and careful selection of breeding animals. Before breeding, cats are tested to identify carriers of the PKD gene and exclude them from reproduction. Important measures include:
- Genetic tests : These help to identify carriers of the PKD gene.
- Careful selection of breeding animals : Only healthy cats that are free from PKD should be used for breeding.
- Buyer education : Breeders inform buyers about PKD and the health of the animals.
These strategies help minimize the risk of PKD spreading in breeding facilities and promote healthy cat populations.
Monitor your cat's health with Flappie
With the Flappie Smart Cat Flap, you can better monitor your cat's health. The flap detects whether your cat comes home alone or with prey. This helps you keep out unwanted prey like birds or mice, which is especially important if your cat has PKD and needs a clean environment.
The Flappie app enhances monitoring with instant notifications about your cat's behavior. You get:
- Real-time updates when your cat uses the flap,
- the possibility to control the cat flap remotely ,
- Access to videos and statistics that give you insight into your cat's activities.
Use this technology to ensure your cat's well-being and visit https://flappie.ch for more information.
Frequently Asked Questions
What are the signs of kidney failure in cats?
The symptoms of kidney failure in cats develop gradually and vary depending on the stage of the disease. In the first stage, there are no visible symptoms. In the later stages, symptoms such as reduced appetite, weight loss, excessive thirst, frequent urination and lethargy may occur. These signs are often similar to those of polycystic kidney disease (PKD).
How long can a cat live with damaged kidneys?
In the end stages of renal failure, the life expectancy of an untreated cat is only about 35 days. However, early diagnosis and consistent treatment can help extend the life expectancy of these cats.
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